Accelerated failure-time model with weighted least-squares estimation: application on survival of HIV positives

نویسندگان

چکیده

Abstract Background Survival analysis is the most appropriate method of for time-to-event data. The classical accelerated failure-time model a more powerful and interpretable than Cox proportional hazards model, provided that imposed distribution homoscedasticity assumptions satisfied. However, real data are heteroscedastic which violates fundamental assumption consequently, statistical inference could be erroneous in modeling. weighted least-squares estimation an efficient semi-parametric approach without assumption, developed recently not often utilized analysis. Thus, this study was conducted to ascertain better performance over methods. Methods We analyzed REAL dataset on Antiretroviral Therapy patients we collected. compared results from methods with revealed estimation. Results found indicated least-square should used analyze accurate, estimates covariates effect since its confidence intervals were shorter it identified significant covariates. Accordingly, survival HIV positives significantly linked age, weight, functional status, CD4 (Cluster Differentiation agent 4 glycoproteins), clinical stages. Conclusions performed best providing effects precise if heteroscedastic. recommend future researchers utilize rather when violated.

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ژورنال

عنوان ژورنال: Archives of public health

سال: 2021

ISSN: ['2049-3258', '0778-7367']

DOI: https://doi.org/10.1186/s13690-021-00617-0